1/16/2024 0 Comments Fibrous scaffolds![]() ![]() ![]() Recently a variety of techniques has been evolved to fabricate nanofibrous scaffolds for biomedical applications such as techniques of phase separation, self-assembly, melt-blowing, and templating system. The technique of electrospinning has produced nanofibrous scaffolds that not only reduced the bulk release of encapsulated drugs but also found useful in developing dual degree delivery systems for post operative surgical treatment of the patients. The nanofibrous scaffolds fabricated with natural and synthetic polymers found to be promising for developing drug delivery systems by electrospinning of blended polymers or through coaxial spinning of two different polymers along with drugs and active agents. The fabrication of electrospun nanofibers using hydrophilic polymers found to be effective in developing fast dissolving delivery systems having reduced drug–drug interactions. Nanofibers have played significant role in various fields of biomedical research ranging from drug delivery to wound healing due to having high surface area and opportunities to tune their properties by varying composition and fabrication parameters. The role of various factors controlling drug distribution in electrospun nanofibrous scaffolds is also discussed to increase the therapeutic efficiency of nanofibrous scaffolds in wound healing and drug delivery applications. Attempts have also been made to highlights the advantages and disadvantages of nanofirbous scaffolds fabricated for biomedical applications using technique of electrospinning. This review highlights the applications and importance of electrospun nanofibrous scaffolds in various fields of biomedical applications ranging from drug delivery to wound healing. Although scaffolds for tissue engineering have been fabricated by various techniques but electrospun nanofibrous scaffolds have shown great potential in the fields of tissue engineering and regeneration. In comparison to other forms of scaffolds, the nanofibrous scaffolds promote cell adhesion, proliferation and differentiation more efficiently due to having high surface to volume ratio. Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |